While environmental factors and pollutants have been linked to a range of neurodevelopmental disorders, genetics has also been found to play a significant role in the development of Autism. More specifically, the gene neuropilin2 has been identified as a key player in regulating the formation of neural circuits in the brain.
Research has shown that mutations in this gene can lead to disruptions in neural connectivity, which can manifest as symptoms of autism and epilepsy. However, the exact mechanisms these mutations impact brain function are still not fully understood.
Investigating neuropilin2
Dr. Viji Santhakumar, a leading neuroscientist at the University of California, Riverside, along with her colleagues at Rutgers University in Newark, New Jersey, have developed a novel “inhibitory neuron selective knockout” mouse model to investigate how neuropilin2 can affect the development and function of inhibitory neurons in the brain.
In their experiment, they observed that the absence of neuropilin2 resulted in impaired migration of inhibitory neurons, disrupting the delicate balance between excitatory and inhibitory signals in the brain. Santhakumar explains that an imbalance in these signals can lead to autism-like behaviors and an increased risk of seizures.
Implication
These findings suggest that targeting specific phases of neuronal development, for example, through regulating the expression of neuropilin2, could potentially prevent the onset of these disorders if detected early on. In a brief interview, Santhakumar expresses the importance of further research in understanding these disorders’ genetic and circuitry components.
By delving deeper into these mechanisms, we may be able to develop more effective interventions for a range of developmental disorders such as autism, attention-deficit/hyperactivity disorder (ADHD), and schizophrenia.
This collaborative study, funded by the Rutgers Brain Health Institute and the New Jersey Council for Autism Spectrum Disorders, employs state-of-the-art techniques in both behavioral and physiological assessments to further explore these processes. With Santhakumar’s expertise and dedication to advancing our understanding of brain circuit function in health and disease, her move from Rutgers University to UCR in 2018 has greatly expanded the potential impact of her research. Through this work, we hope to uncover new insights into the complexities of developmental brain disorders and ultimately improve the lives of those affected by them.
Early detection and intervention in Sacramento
At Sacramento ABA, we understand the importance of early detection and intervention in promoting healthy brain development. That is why we commend Dr. Santhakumar and her colleagues for taking steps towards a better understanding of developmental brain disorders. Our team at Sacramento ABA Therapy is committed to providing personalized and evidence-based interventions for individuals with autism, ADHD, and other developmental disorders.
We believe that individuals can reach their full potential and lead fulfilling lives with the right support and guidance. Contact us today to learn more about our services and how we can help you or your loved one.
